Various synthetic derivatives of natural flavonoids are known to have neuroprotective properties. Rutin is a flavonoid\nthat is an important dietary constituent of food and plant-based beverages having anticonvulsant effect. In view of this, the\npresent study was designed to investigate effect of rutin on pentylenetetrazole (PTZ) kindling induced depression in mice using\nforced swim test. PTZ (35 mg/kg) was administered on alternate days to produce kindled mice. Kindled mice were treated with\n50, 75 and 100 mg/kg of rutin daily and on PTZ administration day 30 min before PTZ. Mean seizure stages were assessed in\nPTZ kindling and these kindled mice were observed for immobility time period in forced swim test for evaluating depression.\nThe results suggest that pre-treatment with rutin at 50, 75 and 100 mg/kg can attenuate seizure severity during the kindling\nprocedure. Additionally, rutin administration significantly decreased the immobility time period in the forced swim test in a\ndose dependant manner. The results of present study concluded that rutin suppress PTZ kindling induced seizures and\nameliorates depression induced by PTZ kindling in mice.
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